THE ULTIMATE GUIDE TO GR

A single nucleotide polymorphism that replaces A with G on the nucleoside 3669 (A3669G) situated in the 3’ end of exon 9b has been explained in a European populace (461). This polymorphism would not alter the amino acid sequence but boosts the balance of GRb mRNA and boosts GRb protein expression, leading to higher inhibition of GRa-induced trans